Objective The UK Human Papillomavirus (HPV) vaccine programme commenced in the autumn of 2008 for year 8 (age 12–13 years) schoolgirls. We examine whether the vaccine should be given when there is a difference of opinion between daughters and parents or guardians. Design Qualitative study using semi-structured interviews. Participants A sample of 25 stakeholders: 14 professionals involved in the development of the HPV vaccination programme and 11 professionals involved in its implementation. Results Overriding the parents' wishes was perceived as problematic (...) and could damage the relationship between school and parents. A number of practical problems were raised in relation to establishing whether parents were genuinely against their daughter receiving the vaccine. Although many respondents recognised that the Gillick guidelines were relevant in establishing whether a girl could provide consent herself, they still felt that there were significant problems in establishing whether girls could be assessed as Gillick competent. In some areas school nurses had been advised not to give the vaccine in the absence of parental consent. None of the respondents suggested that a girl should be vaccinated against her consent even if her parents wanted her to have the vaccine. Conclusions While the Gillick guidelines provide a legal framework to help professionals make judgements about adolescents consenting to medical treatment, in practice there appears to be variable and confused interpretation of this guidance. Improved legal structures, management procedures and professional advice are needed to support those who are assessing competence and establishing consent to vaccinate adolescents in a school setting. (shrink)

This paper presents a short classroom exercise to stimulate student discussion about the rights of shareholders versus the rights of stakeholders. Students are challenged to identify and evaluate their preconceived notions of what constitutes excessive profits. The exercise illustrates why the realization of a large return on investment cannot be used as prima facie evidence that a firm exploited employees, customers, or other stakeholders. This concept is illustrated using datafrom the pharmaceutical industry.

This paper presents a short classroom exercise to stimulate student discussion about the rights of shareholders versus the rights of stakeholders. Students are challenged to identify and evaluate their preconceived notions of what constitutes excessive profits. The exercise illustrates why the realization of a large return on investment cannot be used as prima facie evidence that a firm exploited employees, customers, or other stakeholders. This concept is illustrated using datafrom the pharmaceutical industry.

This paper discusses how the teaching of ethics can be interwoven with the most basic concept in finance: time value of money. Although valuation formulas yield precise numerical answers, they require many assumptions about future economic conditions. If decision makers use false information or erroneous assumptions, they will arrive at an incorrect value estimate, even if the calculations are performed correctly. Thus, the valuation process can be manipulated byunscrupulous participants. This concept is illustrated with references to recent events. Examples appropriate (...) for classroom use are included in an appendix. (shrink)

This paper discusses how the teaching of ethics can be interwoven with the most basic concept in finance: time value of money. Although valuation formulas yield precise numerical answers, they require many assumptions about future economic conditions. If decision makers use false information or erroneous assumptions, they will arrive at an incorrect value estimate, even if the calculations are performed correctly. Thus, the valuation process can be manipulated byunscrupulous participants. This concept is illustrated with references to recent events. Examples appropriate (...) for classroom use are included in an appendix. (shrink)

This paper examines the introduction of European anatomy to Japan via translated medical texts in the eighteenth century. It argues how detailed illustrations of the body found in the texts presented a new discourse by which to objectify and control the body, and new metaphors and analogies by which to view society. Inspection of bodily parts through dissection and the reading of anatomical texts marked a transition to Western forms of science, to ‘reliable’ knowledge which was certified by the social (...) status of the author. By looking at one important text, the Kaitai shinsho [A New Book of Anatomy] , it will be shown that changes in representations of the body reflect the social construction of gender. (shrink)

The endomesoderm gene regulatory network (GRN) of C. elegans is a rich resource for studying the properties of cell‐fate‐specification pathways. This GRN contains both cell‐autonomous and cell non‐autonomous mechanisms, includes network motifs found in other GRNs, and ties maternal factors to terminal differentiation genes through a regulatory cascade. In most cases, upstream regulators and their direct downstream targets are known. With the availability of resources to study close and distant relatives of C. elegans, the molecular evolution of this network can (...) now be examined. Within Caenorhabditis, components of the endomesoderm GRN are well conserved. A cursory examination of the preliminary genome sequences of two parasitic nematodes, Haemonchus contortus and Brugia malayi, suggests that evolution in this GRN is occurring most rapidly for the zygotic genes that specify blastomere identity. BioEssays 28: 1010–1022, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

This Omnibus edition brings together four classic works on Hinduism by renowned scholars, providing the liturgical, historical, anthropological, and individualist's interpretation of the religion. With an introduction by T.N. Madan, this volume will make an excellent and very comprehensivecollector's item on the subject of Hinduism.

The discovery of the first intracellular substrate for insulin, IRS‐1, redirected the field of diabetes research and has led to many important advances in our understanding of insulin action. Detailed analysis of IRS‐1 demonstrates structure/function relationships for this modular docking molecule, including mechanisms of substrate recognition and signal propagation. Recent work has also identified other structurally similar molecules, including IRS‐2, the Drosophila protein, DOS, and the Grb2‐binding protein, Gab1, suggesting that this intracellular signalling strategy is conserved evolutionarily and is utilized (...) by an expanding number of receptor systems. In fact, IRS‐1 itself has been shown to be important in other growth factor and cytokine signalling systems, including growth hormone and several interleukins. Analysis of mice lacking IRS‐1 confirms an important physiological role for this protein in glucose metabolism and general cell growth in the intact animal. Disregulation of the signalling pathways integrated by the IRS proteins may contribute to the pathophysiology of non‐insulin‐dependent diabetes mellitus or other diseases. (shrink)

Platon n’est pas sérieux lorsqu’il conduit Socrate à déduire que la poésie doit être essentiellement narrative avec juste un peu de dialogue. Non seulement cette argumentation est-elle intentionnellement fautive, mais Platon crée aussi un Socrate qui obscurcit à dessein une distinction fondamentale. Le Socrate de Platon fait ensuite semblant d’être confus par son propre obscurcissement. En nous obligeant à nous frayer un passage à travers les broussailles de son argumentation erronée, Platon nous donne l’occasion d’avoir une participation plus profonde aux (...) véritables problèmes sous-jacents et de découvrir son thème : une bonne personne est stoïquement indifférente à la fois au malheur et au bonheur. (shrink)

ABSTRACT: Careful analysis of the details of the text allows us to refine Socrates objections to his definition of manliness as prudent perseverance. He does not appreciate that Socrates objections merely require that he make his definition more precise. Nicias refuses to consider objections to his understanding of manliness as avoiding actions that entail risk. The two sets of objections show that manliness entails first calculating that a risk is worth taking and then subsequently not rejecting that calculation without due (...) consideration. (shrink)

Current interpretations of Plato’s cave are obviously incorrect because they do not explain how what we hear does not come from what we see. I argue that Plato is saying that the colors we receive from our faculty of vision do not cause the sounds that we receive from our faculty of hearing. I also show how we do not see ourselves or one other, how the shadows on the wall of the cave are images of that which casts them (...) and therefore have less reality than them, and how the cave illustrates the divided line’s concern for the relationship between Forms and visible reality. The paper is structured around the two great riddles of the divided line: how Forms can be more real than everyday objects, and how one can know the unhypothesized beginning with complete certainty. I further argue that the puppets that cast shadows stand for the immanent Forms of the Phaedo and also for the moving Forms of the Timaeus. That of which these puppets are themselves images would thus stand for the Forms as they are in themselves of the Phaedo or the indestructible Forms of the Timaeus. ‘Plato used to ask whether the discussion was proceeding from or leading up to fundamental principles, just as in a race course there is a difference between running from the judges to the far end of the track and running back again.’ – Aristotle, Nicomachean Ethics 1095. (shrink)

Current interpretations of Plato’s cave are obviously incorrect because they do not explain how what we hear does not come from what we see. I argue that Plato is saying that the colors we receive from our faculty of vision do not cause the sounds that we receive from our faculty of hearing. I also show how we do not see ourselves or one other, how the shadows on the wall of the cave are images of that which casts them (...) and therefore have less reality than them, and how the cave illustrates the divided line’s concern for the relationship between Forms and visible reality. The paper is structured around the two great riddles of the divided line: how Forms can be more real than everyday objects, and how one can know the unhypothesized beginning with complete certainty. I further argue that the puppets that cast shadows stand for the immanent Forms of the Phaedo and also for the moving Forms of the Timaeus. That of which these puppets are themselves images would thus stand for the Forms as they are in themselves of the Phaedo or the indestructible Forms of the Timaeus. ‘Plato used to ask whether the discussion was proceeding from or leading up to fundamental principles, just as in a race course there is a difference between running from the judges to the far end of the track and running back again.’ – Aristotle, Nicomachean Ethics 1095. (shrink)

It is shown that Plato’s Lysis is full of positive content between the lines. At the close of the dialogue Socrates says that he considers Lysis, Menexenus, and himself to be friends of one another. Following up on the questions which the dialogue leads us to ask yields an explanation ofwhy each of these instances of friendship is, in fact, an instance of friendship. In addition, the dialogue shows that there are five types of motivation for desiring something.

It is shown that Plato’s Lysis is full of positive content between the lines. At the close of the dialogue Socrates says that he considers Lysis, Menexenus, and himself to be friends of one another. Following up on the questions which the dialogue leads us to ask yields an explanation ofwhy each of these instances of friendship is, in fact, an instance of friendship. In addition, the dialogue shows that there are five types of motivation for desiring something.

Socrates contradicts himself when he claims that a good doctor must have the experience of having an unsound body and when he claims that a good judge must have a sound soul, for the unsound of body will not be treated and how a judge decides the case of a good person is a matter of indifference. These pages are really about the meaning of simplicity of soul, and arguing against Glaucon's claim, 'to be moved by self-advantage is the end (...) which it is natural to pursue as good, until forcibly turned aside by law and custom to respect equality'. (shrink)

Even though the first book of the Republic ends with the claim that the definition of justice has not been determined, a careful analysis of the details of Socrates’ arguments with Polemarchus and Thrasymachus yields a definition of justice. Polemarchus should have defended the understanding of justice as helping friends and harming enemies by saying that, because one can use one’s knowledge either to help or to harm, a just person will choose to use his knowledge of an art either (...) to help his friends or to harm his enemies. Socrates’ art of wage-earning is not really an art at all, but merely amounts to having an ulterior motive for doing what one does. Socrates’ true position will be seen to be that just people use their knowledge for the sake of helping people—not for the sake of acquiring some supposed benefit for themselves in the future. (shrink)

This article shows that Plato is discussing Pauline predication and Pauline self-predication in the Phaedo. The key is the recognition that the “something else” of Phaedo 103e2-5 cannot be a sensible object because any such object which participates in Form ‘X’ can sometimes appear not to be x. It is argued that Plato has not written in a straightforward manner, but rather has written a series of riddles for the reader to solve. Thus this dialogue is an example of the (...) playful use of the written word discussed at Phaedrus 275ff. (shrink)